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Postmortem Analysis of Adrenal-Medulla-to-Caudate Autograft in a Patient with Parkinson's Disease Ann Neurol 25:607-614, Hurtig,H.,et al, 1989 See this aricle in Pubmed Article Abstract A 53-year-old physician who had a 10-year history of progressive idiopathic parkinsonism survived for 4 months after an autologous adrenal- medulla-to-right-caudate autograft but he received little clinical benefit.A small number of chromaffin cells in the graft site survived;they expressed neurofilament proteins and chromogranin A,but scant tyrosine hydroxylase.The striatum on both sides showed almost complete loss of{3H} mazindol binding to dopamine-uptake sites;the density of dopamine receptors was decreased adjacent to the transplant but increased rostral to the transplant.These results demonstrate that autografted chromaffin cells can survive for 4 months after transplantation and that related changes in dopamine receptors can be quantified.

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(click to filter results - removes previous filter) brain transplantation dopamine receptor neuropathology neuropathology,brain Parkinson disease Parkinson disease,surgical treatment of Parkinson disease,treatment of treatment of neurologic disorder

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